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Category Alerts


Successful Transition of Cell Line Development With Animal Origin Component Free Media

July 27, 2022
alert level: Medium

Pristine Biologicals Expands Production Capacity

July 14, 2022
alert level: Medium

Thermo Fisher Expands Animal Origin Free Media Manufacturing Capacity

August 08, 2022
alert level: High

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Serum Market Monitoring Dashboard

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Serum Industry Benchmarks

Savings Achieved

(in %)

The average annual savings achieved in Serum category is 20.10%

Payment Terms

(in days)

The industry average payment terms in Serum category for the current quarter is 54.3 days

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    Serum Market Intelligence

    global market outlook

      • The global market size is 660,000 Liters in 2021 and the market is expected to grow at a CAGR of approx. 8–9 percent to 1077,000 liters by 2027
      • The APAC region is leading in the supply of FBS, limited demand exists for FBS in the Asian region. Several organizations in North America have been involved in the development of COVID-19 vaccines and drugs, which has increased the demand for FBS
      • Australia and New Zealand-origin serum or FBS are considered to be superior to other regions of origin. This is because of the low BSE or disease risk that these regions hold. However, the serum activity is found to be similar across all serums and other alternatives, like US-origin serum, can be considered.
      • The US-origin serum is also gaining more popularity ever since its upgrade to the negligible BSE risk category by OIE. Brazil or South American origin serum is considered as a low-cost alternative for the US-origin serum. Currently, it is more prevalent in the R&D segment than in manufacturing
      • Fetal bovine blood is the basic raw material used in the manufacture of Fetal Bovine Serum. The price of fetal bovine blood varies significantly due to various factors, such as herd rebuilding, drought, etc. This is the major cost component in the manufacturing of Fetal Bovine Serum

    Serum market frequently asked questions

    The worldwide serum supply in 2020 was around 704,000 L. As per Beroe’s category intelligence report, the global serum market will grow at 4-5% CAGR over the next five years, reaching nearly 899,000 L total volume.

    Rapid growth in the biopharmaceutical industry has been the primary driver for the global serum market. The fetal bovine serum (FBS) has been supplementing cell culture media for several decades. Furthermore, increasing demand from emerging regions, such as South Korea and other developing nations, will likely offer another leg of growth.

    While the US holds a significant revenue share in the global serum market, players prefer Australia and New Zealand for sourcing FBS owing to the lowest risk of transmissible spongiform encephalopathy (TSE) and bovine spongiform encephalopathy (BSE).

    Specific ethical, scientific, and supply challenges have compelled researchers to look for a substitute for FBS. Moreover, the supply of FBS is limited and is subject to various factors including, cattle cycles, beef demand, and weather patterns. Furthermore, issues with the supply chain monitoring of FBS are impacting manufacturers’ bottom lines.

    While there is a shift towards artificial serum, animal-based serums, especially FBS, find use in specific applications. Further, think tanks have dedicated several years to research in order to discover a substitute to FBS; however, they have yet to find a solid alternative.

    The US, Brazil, and Australia are the major serum producers worldwide. While the North American serum market is growing at a 4-5% CAGR, the market size in Europe is expanding at around 5% CAGR.

    Serum market report transcript

    Global Market Outlook on Serum 

    • Supply market for FBS is split across the US, Australia, Brazil, etc. The US contributes to the highest market share, which is greater than Australia and New Zealand

    • Dual sourcing of FBS is usually followed by major pharmaceutical companies for commercial manufacturing and R&D applications

    • Suppliers are evaluated for long-term supply assurance and traceability of serum

    • Usage of South American origin FBS has increased, particularly in the research community

    Serum Market Overview 

    • The volume of FBS produced globally in 2022 is estimated to be around 670,000 L. The US, Australia, New Zealand, and Brazil are some of the major regions for FBS production.

    • The global FBS market is projected to grow at a rate of 8–9 percent for the next few years and reach a total volume of nearly 1094,000 L by 2028

    • The FBS volume is increased in 2022 compared to 2021, since the slaughter rates have increased in 2022 compared to 2021

    • New Zealand and Australia, having the lowest risk of BSE and TSE, are the most preferred locations for sourcing FBS

    • Increasing demand for FBS, coupled with slow growth in raw material fetal bovine blood (FBB), is one of the key challenges in the market

    • Although there is a shift toward artificial serum, there are certain applications for animal-based serum (especially, FBS), which cannot be overseen

    Industry Drivers and Constraints : Serum 

    Health status of the country of origin affects the price of FBS although the place of origin does not affect the product quality or activity.


    • Demand for FBS has been driven by the rapid growth in the biopharmaceutical industry. Cell culture media has been supplemented by FBS for many decades now

    • Demand from new regions, like South Korea and other developing countries, is expected to fuel the demand for FBS

    • FBS sourced from New Zealand and Australia are always preferred over any other serum, since they are free from any risk and assumed to offer better results


    • Due to the certain scientific, ethical and supply challenges, researchers have been forced to identify an alternative for FBS

    • Supply of FBB is finite and it often affected by factors, like weather pattern, dairy market, cattle cycles, and beef demand

    • Issues in traceability with the supply chain of FBS is a crucial factor that affects market growth

    Cost Structure Analysis : Serum 

    • Major cost component in the manufacturing of FBS is the raw material Fetal bovine blood. Its availability and origin drive the final price of FBS

    • Availability of the major raw material fetal bovine blood may be affected by climatic conditions, herd rebuilding, drought, etc.

    • Fetal bovine blood is the basic raw material used in the manufacture of FBS. The price of fetal bovine blood varies significantly due to various factors, such as herd rebuilding, drought, etc. This is the major cost component in the manufacturing of FBS

    • Considerable amount of labor is involved in the manufacture of FBS and also in ensuring that the serum processed is of utmost quality and meets the required standards

    • Quality and compliance are very crucial in the manufacturing of FBS and hence, it occupies nearly 5 percent of the total FBS manufacturing cost

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