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In-Vivo Toxicology Testing
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Intelligence covers market and price outlook, SWOT analysis, demand & supply drivers, engagement models and Procurement best practices

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Intelligence on category covers the following aspects market outlook, supply market, SWOT analysis, Cost components & Price outlook, Demand and supply drivers, Engagement Models and Procurement Best Practices

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Intelligence covers market and price outlook, SWOT analysis, demand & supply drivers, engagement models and Procurement best practices

1

Intelligence on category covers the following aspects market outlook, supply market, SWOT analysis, Cost components & Price outlook, Demand and supply drivers, Engagement Models and Procurement Best Practices

manage-risk

Assess Supplier Risk based on key risk and compliance parameters

1

Supplier assessment covers the following parameters Financial Risk, Ethical, Labor, Environmental Compliance, IT Security.

2

Supplier assessment is powered by world’s leading data partners including D&B, CreditSafe, Dow Jones, Refinitiv, Orpheus

discover-supplier

Identify right fit suppliers based on your selection criteria including revenue, capabilities, certification, geography

1

Select suppliers based on industry, country, classification from a database of 4.2 mn suppliers. Get detailed supplier profiles with supplier capabilities, revenue, certifications, risk ratings

assess-category-perforamnce

Benchmark your category performance against peers and the market

1

Measure category performance on 15 key parameters across cost, risk and strategy KPIs

source-market-indices

Get information on key factors affecting your supply

1

Source Macro Data and Market Indices information from leading data sources across these key areas - Labor Rates, Currency, Energy, Country Risk, Trade Flow/Transportation, Port Data, Tariff, Weather and Epidemics

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Report Coverage

  • Cost Break up for In-vivo Toxicology Services
  • Pricing Model Adoption
  • Regional Analysis

Table of contents

  1. In-Vivo Toxicology Testing Executive Summary/COVID Impact Update
  2. Executive Summary
  3. COVID Impact Update
  1. In-Vivo Toxicology Testing Market Analysis
  2. Market Snapshot
  3. Industry Trends
  4. Regional Analysis
  5. Porter's five forces analysis
  6. SWOT
  7. Engagement Model: Adoption Rate
  8. Cost and Pricing Model
  1. Market Monitoring Insights
  2. Cost Drivers and Cost Structure
  1. Billing Rates Benchmarking
  2. Billing Rates Overview
  3. In-Vivo Toxicology Testing-Billing Rates
  4. Factors Influencing In-Vivo Toxicology Testing Billing Rate
  1. Sourcing Practices
  2. Sourcing Overview

 

  1. Supplier Section
  2. Key Global Suppliers Global Supplier List and Capabilities
  3. Key Global Supplier Profile
  4. Key Global Supplier: SWOT

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Global Market Outlook on In-Vivo Toxicology Testing 

  1. Outsourcing of this category by large pharma has shifted to a more consolidated state, with two or three preferred suppliers,and one or two niche suppliers
  2. The focus is on novel technology and therapeutic models, to support the global in-vivo toxicology requirements
  3. CROs are now embedding the 3R (Replace, Refine and Reduce) principle, in order to reduce the number of animals used for toxicology studies
  4. Universitiesdevelop a free online kidney atlas that will enable stem cell scientists to generate human-like tiny kidneys. This will ease testing of new drugs and creating renal replacement therapies

Pre-clinical Toxicology Industry Trends

Increased protest against animals used in pharma research have led to numerous technologies offering alternatives to animal  testing. Also, regulatory compliances mandate that service providers restrict the number of in-vivo models, through the  application of the 3R principle

3R Principle

  • CROs are now embedding the 3R (Replace, Refine and Reduce) principle, in order to reduce the number of animals used for toxicology studies
  • On an average, large pharma companies have reduced 20–30 percent of the animals used for research between 2013 and 2016

Agrochemical Industry Demand

  • Toxicology testing demand is expected to grow at 4–5 percent for the next five years. This growth will be driven by demand for chemicals, in order to increase crop yields; prompted by the growing global population and limited land for agriculture
  • The recurring need for testing services, due to the regulatory requirement for re-registration every 10 years, for agro-chemicals is already on the market
  • REACH initiative testing backlog, and an anticipated future testing is expected to create significant demand through 2025

Pricing

  • Pricing for safety testing has improved in 2016–2017 by 2-3 percent, compared to 2012–2015, when the pricing remained stagnant
  • Prices are not expected to improve further in 2017, as capacity utilization has not reached the optimal level (85 percent)

Alternatives

  • Organovo concluded collaboration agreements with L'Oréal, USA; and Merck in 2015, and launched the world's first commercially available 3D printed human tissue that has the potential to replace anima testing
  • Similarly, BASF and Sumitomo have teamed up to develop an in-vitro alternative to animal based chemical testing in 2015
  • Cyprotex (the largest in-vitro and in-silico tox CRO in the world) launched its new in-silico modelling solution, ChemTox, which predicts genotoxicity and rat LD50 directly from the chemical structure. LD50 is a commonly determined parameter in pre-clinical toxicity studies, representing the dose that causes death in 50 percent of the test group. Using models such as those in ChemTox, to predict this parameter, will have obvious ethical benefits in reducing animal toxicity testing
  • Canadian Centre for Alternatives to Animal Methods (CCAAM) opened in October 2017. The centre will carry out multidisciplinary basic research making use of human biological samples rather than conducting in vivo or in vitro tests using animals or animal cell

Engagement Model: Adoption Rate

Strategic deals involving lift-out in preclinical toxicology services by the pharmaceutical companies would increase, in contrast to the current scenario, where the widely adopted (45 percent) engagement model is project by project, as it would help in reducing their fixed cost by shutting down or transferring the toxicology facilities that are under-utilized

Engagement Model Adoption: 2016 

  • Majority of the suppliers (small Biotech) were adopting the project by project model, as the volume of work is not large and this helps to establish a relationship before engaging into a strategic partnership
  •  Adoption of strategic partnerships have increased from 17 percent in 2012 to over 30 percent in 2015–2016
  • Currently, Charles River earns more than 30 percent of its revenues from strategic relationships (25 percent in 2014)

Market Overview

In vivo toxicology services is a highly fragmented supply tail, giving sponsors high bargaining power. Service providers, on the other hand, provides allied and proactive services to their sponsors, to differentiate among themselves in the in vivo toxicology market. According to in vivo toxicology studies, industrial competition is expected to further increase, as suppliers differentiate themselves with the service (alternatives/technology) capabilities they offer. Threat of substitutes will be extremely low in the market, as alternate testing methods have not replaced in-vivo testing fully, and are at best seen as supplements only. The in vivo toxicology market is highly characterized by early stage attrition, and increased regulatory mandates. Also, the usage of in-vitro and in-silico technologies in ADME and toxicology are the latest trends.

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